abstract：:Inner hair cells (IHCs) were isolated from the 3rd and 4th turn of the guinea-pig cochlea using a new microsurgical technique. Microelectrode impalements in vitro with conventional microelectrodes yielded intracellular potentials of -14 +/- 7 mV (mean +/- SD, N = 43) at 24 degrees C. This suggested depletion of intrac...

journal_title：Hearing research

authors： Gitter AH,Zenner HP

更新日期：1990-04-01 00:00:00

abstract：:Endocochlear potential (EP) and cochlear microphonics (CM) were recorded during the perilymphatic perfusion with forskolin known as an adenylate cyclase stimulant. Forskolin produced a reversible EP elevation in a dose-dependent manner. Perfusion with 1,9-dideoxy-forskolin, an analogue of forskolin that does not stimu...

journal_title：Hearing research

authors： Doi K,Mori N,Matsunaga T

更新日期：1990-04-01 00:00:00

abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...

journal_title：Hearing research

authors： Wang JA,Dong WJ,Chen JS

更新日期：1990-03-01 00:00:00

abstract：:Spontaneous synaptic activity in afferent fibers innervating hair cells of the lateral line organ was monitored with micropipettes at visually identified locations near the peripheral terminations of the fibers. Spontaneous action potentials as well as spontaneous excitatory post-synaptic potentials (EPSPs) were obser...

journal_title：Hearing research

authors： Sewell WF

更新日期：1990-02-01 00:00:00

abstract：:Distortion-product emissions at 2f1-f2 were measured in developing, pigmented rats to determine the characteristics of the functional onset and maturation of these emitted responses. Distortion-product testing was conducted on postnatal days 12, 14, 18, 21, 24, 28, and 51. The geometric-mean frequencies of the primari...

journal_title：Hearing research

authors： Henley CM 3rd,Owings MH,Stagner BB,Martin GK,Lonsbury-Martin BL

更新日期：1990-01-01 00:00:00

abstract：:Acoustic distortion has been measured from the ear canals of guinea pigs treated with the aminoglycoside antibiotic gentamicin. The correlation between pre- and post-treatment levels of distortion can be related to the extent of outer hair cell (OHC) pathology induced by gentamicin. All animals that were treated and s...

journal_title：Hearing research

authors： Brown AM,McDowell B,Forge A

更新日期：1989-11-01 00:00:00

abstract：:We examined calcitonin-gene related peptide (CGRP)-like immunoreactivity in the guinea pig organ of Corti at both the light and electron microscope level using immunofluorescence and immunoperoxidase techniques. We observed strong CGRP-like immunoreactivity in the inner spiral bundle and tunnel spiral bundle in all tu...

journal_title：Hearing research

authors： Sliwinska-Kowalska M,Parakkal M,Schneider ME,Fex J

更新日期：1989-10-01 00:00:00

abstract：:Aldosterone-Type I and dexamethasone-Type II/IB receptor complexes were identified in cytosol prepared from both cochlear and vestibular tissue samples. The specific binding capacity of Type I receptors in the cochlear tissues was approximately equal to that in the vestibular tissues. Likewise, the binding capacity of...

journal_title：Hearing research

authors： Rarey KE,Luttge WG

更新日期：1989-09-01 00:00:00

abstract：:We report the changes in auditory function that occurred at selected intervals following exposure to an intense pure-tone stimulus. One day old chicks were exposed to a 0.9 kHz tone for 48 h at 120 dB. At 0, 1, 3, 6, 9, 12 and 15 days after exposure, cochlear nucleus sound-evoked potentials were used to assess thresho...

journal_title：Hearing research

authors： McFadden EA,Saunders JC

更新日期：1989-09-01 00:00:00

abstract：:Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...

journal_title：Hearing research

authors： Kaukoranta E,Sams M,Hari R,Hämäläinen M,Näätänen R

更新日期：1989-08-01 00:00:00

abstract：:Thresholds to sinusoidal and biphasic pulsatile electrical stimuli were measured in two patients with electrodes positioned on the cochlear nucleus. The threshold functions differ from those observed in patients with scala tympani electrodes, primarily at low sinusoidal frequencies and long pulse widths. This differen...

journal_title：Hearing research

authors： Shannon RV

更新日期：1989-06-15 00:00:00

abstract：:Electrical stimulation of the cochlea with a multiple-electrode array is best accomplished using pulsatile instead of continuous stimulation. The optimum shapes of electrical pulses for this purpose are still uncertain due to a lack of knowledge about their stimulation efficiency and requirements of the encoding strat...

journal_title：Hearing research

authors： Wiler JA,Clopton BM,Mikhail MA

更新日期：1989-06-01 00:00:00

abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...

journal_title：Hearing research

authors： Rouiller EM,Rodrigues-Dagaeff C,Simm G,De Ribaupierre Y,Villa A,De Ribaupierre F

更新日期：1989-05-01 00:00:00

abstract：:Spike potentials were recorded from single, afferent fibres in the pigeon auditory nerve. Pure-tone stimuli were presented in quiet and in combination with wide band noise. Presented alone, tones produced tuned response areas; noise generally drove spike rate to well above the spontaneous rate measured in quiet. When ...

journal_title：Hearing research

authors： Hill KG,Mo J,Stange G

更新日期：1989-05-01 00:00:00

abstract：:The C3H/lpr autoimmune strain mouse is a model for spontaneous systemic lupus erythematosus. Inner ear structure and function were examined during systemic autoimmune disease progression to identify correlated auditory system pathology. Onset of the systemic disease occurred at 2-3 months of age and was characterized ...

journal_title：Hearing research

authors： Trune DR,Craven JP,Morton JI,Mitchell C

更新日期：1989-03-01 00:00:00

abstract：:The waveforms of the auditory evoked magnetic field in normal-hearing individuals and patients suffering from tinnitus are distinctly different. In tinnitus patients, the magnetic wave M200 (corresponding to the electric wave P200, or P2) is delayed and only poorly developed or even completely missing, while the ampli...

journal_title：Hearing research

authors： Hoke M,Feldmann H,Pantev C,Lütkenhöner B,Lehnertz K

更新日期：1989-02-01 00:00:00

abstract：:Age pigment in the sensory and supporting cells was a prominent characteristic distinguishing old saccules from young. However, the pigment was not distributed uniformly throughout the sensory epithelium but displayed cell-specific patterns of accumulation. The highest cytoplasmic volume density was in the old support...

journal_title：Hearing research

authors： Hubel SB,Park JC

更新日期：1989-01-01 00:00:00

abstract：:The structure of the tectorial membrane of the chick was evaluated by scanning electron microscopy (SEM), using standard techniques, and, for the first time, by studying unfixed tectorial membranes with video-enhanced light microscopy techniques (AVEC-DIC). The SEM pictures show a widely varying morphology, ranging fr...

journal_title：Hearing research

authors： Runhaar G

更新日期：1989-01-01 00:00:00

abstract：:In order to study the effects of efferent activity, olivocochlear efferents were stimulated with an electrode in the fourth ventricle at the decussation of the crossed olivocochlear bundle (midline-OCB stimulation) or with an electrode at the brainstem origin of medial efferents (MOC stimulation). Tuning curves, or si...

journal_title：Hearing research

authors： Guinan JJ Jr,Gifford ML

更新日期：1988-12-01 00:00:00

abstract：:The effects of glycerol, urea and mannitol on the structure of the murine endolymphatic sac were investigated at various time intervals after their administration. Within 15 min after administration of glycerol and urea the lumen of the endolymphatic sac was partially collapsed and the density of its contents was incr...

journal_title：Hearing research

authors： Erwall C

更新日期：1988-11-01 00:00:00

abstract：:Action potentials recorded extracellularly from neurons within the caudal cochlear nuclei of developing cats exhibited distinctive temporal characteristics (i.e., rhythmic responses) in response to long-duration acoustic stimuli including both tone and noise bursts. Unlike the homogeneous response characteristics of a...

journal_title：Hearing research

authors： Walsh EJ,McGee J

更新日期：1988-11-01 00:00:00

abstract：:Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased wi...

journal_title：Hearing research

authors： Quirk WS,Dengerink HA,Bademian MJ,Hall KW,Wright JW

更新日期：1988-11-01 00:00:00

abstract：:The dynamic properties of single olivocochlear efferent neurones in the guinea pig cochlea were examined using sinusoidally amplitude modulated (AM) pure tones. The neural discharge, when displayed as a cyclic histogram, clearly followed the rapid fluctuations in the continuous input sound. Modulation transfer functio...

journal_title：Hearing research

authors： Gummer M,Yates GK,Johnstone BM

更新日期：1988-10-01 00:00:00

abstract：:Single-unit recordings from neurons in the torus semicircularis of Rana ridibunda were analyzed to determine the degree to which these neurons can detect acoustic stimuli superimposed on continuous, broad-band noise. In the first series of trials the stimuli were tone pulses 25 ms long, 5 dB above threshold, and at th...

journal_title：Hearing research

authors： Joermann G

更新日期：1988-09-15 00:00:00

abstract：:The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...

journal_title：Hearing research

authors： Erwall C,Jansson B,Friberg U,Rask-Andersen H

更新日期：1988-09-01 00:00:00

abstract：:Intracellular recordings were made from both inner and outer hair cells (IHC, OHC) in the basal coil of the guinea pig cochlea before, during and after the animal was exposed to loud, pure tones. Following multiple loud tones both types of sensory cells demonstrate a culmulative decrease in their voltage responses to ...

journal_title：Hearing research

authors： Cody AR,Russell IJ

更新日期：1988-09-01 00:00:00

abstract：:Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...

journal_title：Hearing research

authors： Liberman MC

更新日期：1988-07-15 00:00:00

abstract：:Eighth nerve endings and neuronal types in the nucleus magnocellularis were analyzed in the red-eared turtle (Chrysemys scripta elegans). One group of turtles had horseradish peroxidase (HRP) injected into the surgically exposed inner ear. Following injection the animals survived for 3-5 days and then their 8th nerve ...

journal_title：Hearing research

authors： Browner RH,Marbey D

更新日期：1988-06-01 00:00:00

abstract：:In previous studies describing the effects of electrically stimulating the olivocochlear bundle, it seems possible that both medial and lateral (MOC and LOC) efferents may have been stimulated. To selectively stimulate MOC efferents, we used an electrode placed at the origin of the MOC efferents in the brainstem (MOC ...

journal_title：Hearing research

authors： Guinan JJ Jr,Gifford ML

更新日期：1988-05-01 00:00:00

abstract：:Otoacoustic emissions in both ears of a rhesus monkey exhibiting stable spontaneous emissions (SOEs) were monitored over a 1-year period. The amplitudes and frequencies of both SOEs and stimulus-frequency emissions (SFEs) were routinely recorded, while transiently evoked (EOE) and distortion-product emissions (DPEs), ...

journal_title：Hearing research

authors： Martin GK,Lonsbury-Martin BL,Probst R,Coats AC

更新日期：1988-04-01 00:00:00

abstract：:The incidence and severity of audiogenic seizures in kanamycin (KM)-treated rat pups, from a Wistar strain which is inherently seizure-resistant, was analyzed as a function of (a) postnatal age at the time of KM injection (i.p.) and (b) KM dosage. The vigor of the pinna reflex response on postnatal day (PND) 28 was co...

journal_title：Hearing research

authors： Pierson MG,Swann JW

更新日期：1988-01-01 00:00:00

abstract：:Gerbils exhibit a unique encephalopathy characterized by spongioform lesions in the neuropil of the cochlear nucleus and that others have recently described. The present results suggest that the course of this degenerative disorder is affected by acoustic experience. In gerbils in which acoustic stimulation was limite...

journal_title：Hearing research

authors： McGinn MD,Faddis BT

更新日期：1987-12-31 00:00:00

abstract：:A field potential could be recorded in the deep layers of the superior colliculus (SCd) in the guinea pig following presentation of pure tone bursts at frequencies between 1 and 22 kHz, bursts of white noise, and clicks presented in the free field. The potentials evoked by these stimuli at different intensities had tw...

journal_title：Hearing research

authors： Carlile S,Pettigrew AG

更新日期：1987-12-01 00:00:00

abstract：:Immunocytochemical methods were used to examine cryosections of the embryonic and neonatal chicken cochlea in order to study the histological distribution of the Na+,K+-ATPase molecule during maturation. In complementary studies the Na+,K+-ATPase capacity of microdissected freeze-dried substructures of the cochlea was...

journal_title：Hearing research

authors： Schneider ME,Cotanche DA,Fambrough DM,Saunders JC,Matschinsky FM

更新日期：1987-11-01 00:00:00

abstract：:To assess the effects of extracochlear electrical stimulation on cochlear structure, guinea pigs were implanted and stimulated with single middle ear electrodes either at round window or promontory sites, and their cochleae examined by transmission electron microscopy. Implanted but unstimulated, or unimplanted contro...

journal_title：Hearing research

authors： Dodson HC,Walliker JR,Bannister LH,Douek EE,Fourcin AJ

更新日期：1987-11-01 00:00:00

abstract：:The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same through...

journal_title：Hearing research

authors： Park JC,Hubel SB,Woods AD

更新日期：1987-01-01 00:00:00

abstract：:Cyclic histograms of the responses of single auditory ganglion cells in the guinea pig were recorded during stimulation with amplitude modulated tones. Modulation frequencies ranged from 10 Hz to 800 Hz. The response histograms, phase-locked to the modulation signals, were analysed for mean action potential rate and f...

journal_title：Hearing research

authors： Yates GK

更新日期：1987-01-01 00:00:00

abstract：:Interactions between the statoacoustic ganglion and sensory vestibular epithelia have been investigated using different methods of organ and tissue cultures taken from mouse embryos on gestation day 13. Ultrastructural and biochemical observations of the degree of maturation of vestibular sensory cells and ganglion ne...

journal_title：Hearing research

authors： Raymond J

更新日期：1987-01-01 00:00:00

abstract：:To create experimental lesions localized to the low frequency region of the organ of Corti, a cryoprobe was applied to the apical area of 37 cochleas from 26 adult chinchillas. Twenty cochleas were exposed to single applications of a cryoprobe for 2.5, 3.0 and 3.5 min; 17 cochleas were exposed to two applications of 1...

journal_title：Hearing research

authors： Brown JN,Nuttall AL

更新日期：1987-01-01 00:00:00

abstract：:It is still a matter of debate whether neurons in the higher central nervous system of anurans become progressively more sharply tuned to sounds that have a behavioral importance or that such coding is performed by (small) groups of neurons. The approach we have taken to investigate this matter comprises simultaneous ...

journal_title：Hearing research

authors： Eggermont JJ,Epping WJ

更新日期：1987-01-01 00:00:00